As thousands of healthy research participants are being included in small and large imaging studies, it is essential that dilemmas raised by the detection of incidental findings are adequately handled. Current ethical guidance indicates that pathways for dealing with incidental findings should be in place, but does not specify what such pathways should look like. Building on an interview study of researchers’ practices and perspectives, we identified key considerations for the set-up of pathways for the detection, management and communication of (...) incidental findings in imaging research. We conducted an interview study with a purposive sample of researchers at research facilities across the Netherlands. Based on a qualitative analysis of these interviews and on existing guidelines found in the literature, we developed a prototype ethical framework, which was critically assessed and fine-tuned during a two-day international expert meeting with bioethicists and representatives from large population-based imaging studies from the United Kingdom, Germany, Sweden and Belgium. Practices and policies for the handling of incidental findings vary strongly across the Netherlands, ranging from no review of research scans and limited feedback to research participants, to routine review of scans and the arrangement of clinical follow-up. Respondents felt that researchers do not have a duty to actively look for incidental findings, but they do have a duty to act on findings, when detected. The principle of reciprocity featured prominently in our interviews and expert meeting. We present an ethical framework that may guide researchers and research ethics committees in the design and/or evaluation of appropriate pathways for the handling of incidental findings in imaging studies. The framework consists of seven steps: anticipation of findings, information provision and informed consent, scan acquisition, review of scans, consultation on detected abnormalities, communication of the finding, and further clinical management and follow-up of the research participant. Each of these steps represents a key decision to be made by researchers, which should be justified not only with reference to costs and/or logistical considerations, but also with reference to researchers’ moral obligations and the principle of reciprocity. (shrink)

This interview study investigates the short- and long-term implications of incidental findings detected through brain imaging on research participants’ lives and their surroundings. For this study, nine participants of the Rotterdam Scan Study with an incidental finding were approached and interviewed. When examining research participants’ narratives on the impact of the disclosure of incidental findings, the authors identified five sets of tensions with regard to motivations for and expectations of research participation, preferences regarding disclosure, short- and long-term impacts and impacts (...) on self and others. The paper shows: that the impact of incidental findings may be greater than participants at first let on; incidental findings can have significant effects on participants’ social environment; and participants may not feel prepared for disclosure even if incidental findings have been discussed during the informed consent process. The authors call for investigators to be aware of research participants’ experiences and these short- and long-term impacts when designing suitable courses of action for the detection and management of incidental findings in research settings. (shrink)

According to historical theories of biological function, a trait's function is determined by natural selection in the past. I argue that, in addition to historical functions, ahistorical functions ought to be recognized. I propose a theory of biological function which accommodates both. The function of a trait is the way it contributes to fitness and fitness can only be determined relative to a selective regime. Therefore, the function of a trait can only be specified relative to a selective regime. Apart (...) from its desirable pluralism, only this view of relational function can support the function/accident and function/malfunction distinctions commonly thought to be part of the concept of function. Furthermore, only relational function correctly characterizes the explanatory consequences of function attributions in evolutionary biology. (shrink)

First, The doctrine of naturalism, That reality is spatio-Temporal, Is defended. Second, The doctrine of materialism or physicalism, That this spatio-Temporal reality involves nothing but the entities of physics working according to the principles of physics, Is defended. Third, It is argued that these doctrines do not constitute a "first philosophy." a satisfactory first philosophy should recognize universals, In the form of instantiated properties and relations. Laws of nature are constituted by relations between universals. What universals there are, And what (...) relations hold between them, Must be discovered "a posteriori" by scientific investigation. (shrink)

This paper examines the deontic logic of the Talmud. We shall find, by looking at examples, that at first approximation we need deontic logic with several connectives: O T A Talmudic obligation F T A Talmudic prohibition F D A Standard deontic prohibition O D A Standard deontic obligation. In classical logic one would have expected that deontic obligation O D is definable by $O_DA \equiv F_D\neg A$ and that O T and F T are connected by $O_TA \equiv F_T\neg (...) A$ This is not the case in the Talmud for the T (Talmudic) operators, though it does hold for the D operators. We must change our underlying logic. We have to regard {O T , F T } and {O D , F D } as two sets of operators, where O T and F T are independent of one another and where we have some connections between the two sets. We shall list the types of obligation patterns appearing in the Talmud and develop an intuitionistic deontic logic to accommodate them. We shall compare Talmudic deontic logic with modern deontic logic. (shrink)

The development of comparative biology has been of interest to philosophers and historians. Particular attention has been placed on the ‘war’ of the 1970s and 1980s, the apparent dispute among those who preferred this or that methodology. In this contribution we examine the history of comparative biology from the perspective of fundamentals rather than methodologies. Our examination is framed within the artificial—natural classification dichotomy, a viewpoint currently lost from view but worth resurrecting.

It is not certain when or by whom S0009838800011642_inline1 and S0009838800011642_inline2 were first technically distinguished as genus and species. The distinction does not appear in Plato's extant writings, whereas Aristotle seems to take it for granted in the Topics, which is usually regarded as among his earliest treatises. In his dialogues Plato seems able to use S0009838800011642_inline3 interchangeably to denote any group or division in a diairesis, including the group that is to be divided.

The role of the environment in producing the correct classical limit in the Bohm interpretation of quantum mechanics is investigated, in the context of a model of quantum Brownian motion. One of the effects of the interaction is to produce a rapid approximate diagonalisation of the reduced density matrix in the position representation. This effect is, by itself, insufficient to produce generically quasi-classical behaviour of the Bohmian trajectory. However, it is shown that, if the system particle is initially in an (...) approximate energy eigenstate, then there is a tendency for the Bohmian trajectory to become approximately classical on a longer time-scale. The relationship between this phenomenon and the behaviour of the Wigner function post-decoherence is discussed. (shrink)

It is not certain when or by whomandwere first technically distinguished asgenusandspecies. The distinction does not appear in Plato's extant writings, whereas Aristotle seems to take it for granted in theTopics, which is usually regarded as among his earliest treatises. In his dialogues Plato seems able to useinterchangeably to denote any group or division in a diairesis, including the group that is to be divided.

The Units of Selection debate is a dispute about the causes of population change. I argue that it is generated by a particular `dynamical'' interpretation of natural selection theory, according to which natural selection causes differential survival and reproduction of individuals and natural selection explanations cite these causes. I argue that the dynamical interpretation is mistaken and offer in outline an alternative, `statistical'' interpretation, according to which natural selection theory is a fancy kind of `bookkeeping''. It explains by citing the (...) statistical structure of a population and not by citing the causes of survival and reproduction. From the perspective of the statistical interpretation there is no substantive Units of Selection issue. (shrink)

Arda Denkel, in "Real Resemblances," argues for a moderate Nominalism where substances objectively have properties and relations, the latter being particulars, but dependent particulars, grouped into classes by objective relations of resemblance. This view is contrasted unfavorably with the view that properties and relations are universals instantiated by particulars. It is conceded that Denkel's scheme has much to commend it. But it is argued that the universals view has much more to be said for it than Denkel allows, and that (...) it is indeed, on balance, the superior view. (shrink)

John Foster’s book, The Nature of Perception, is written to defend his Idealist, or Berkeleyan, theory of perception. One view that he is concerned to reject is what he usefully calls the ‘Cognitivist’ theory of perception. I am named as one of its defenders. His critique of the theory serves me as a good starting point and as a stimulus for a new defense of the theory.

Totality states of affairs (Russell's 'general facts') are defended against Martin's criticisms. Although higher-order, they are not 'abstract in Quine's sense. If space-time is the whole of being, and if it can be seen as a vast conjunction of states of affairs, then the state of affairs that this is the totality of lower-order states of affairs is not additional to, but completes, space-times. If totality states of affairs are admitted, then there seems no need for any further negative states (...) of affairs additional to totality states of affairs. (shrink)

An ontology of geographic kinds is designed to yield a better understanding of the structure of the geographic world, and to support the development of geographic information systems that are conceptually sound. This paper first demonstrates that geographical objects and kinds are not just larger versions of the everyday objects and kinds previously studied in cognitive science. Geographic objects are not merely located in space, as are the manipulable objects of table-top space. Rather, they are tied intrinsically to space, and (...) this means that their spatial boundaries are in many cases the most salient features for categorization. The ontology presented here will accordingly be based on topology (the theory of boundary, contact and separation) and on mereology (the theory of extended wholes and parts). Geographic reality comprehends mesoscopic entities, many of which are best viewed as shadows cast onto the spatial plane by human reasoning and language. Because of this, geographic categories are much more likely to show cultural differences in category definitions than are the manipulable objects of table-top space. (shrink)

In this rehabilitation of the relational transaction of compromising, we follow Paul Ricoeur in arguing that at the intersection of diverse orders of value, compromising rises to the level of a moral duty. Thus, an ethics of compromise, rooted in recognition theory, provides a virtuous means of moral engagement with otherness in the context of pluralism. Virtue theory needs to move in an interactive direction by enlisting moral epistemology, for a shift in focus from the individual agent to the interaction (...) of agents ; attending to the political theorists and sociologists who ground meaningful compromise in mutual recognition; and tailoring such recognition to bounded human capacities for rationality and empathy, via "psychological realism"—all in service of attenuating the discomfort and even moral pain that agents may feel when called upon to compromise. (shrink)

It is argued that it is possible that all properties are categorical, contrary to the arguments of Franklin that there must be dispositionality "all the way down". The tasks for which dispositionality is alleged to be needed can be fulfilled by laws of nature, which are categorical relations between universals.

The principle that a moving body must continue to move unless something stops it was not known to Aristotle nor even unconsciously assumed by him. The effect of this ignorance upon his philosophy was discussed in C.Q. 1939, p. 129 f. It forbade him to conceive of a mechanist theory in the nineteenth-century sense. It enabled him to hold, what must seem self-contradictory to us, that all events have definable causes without there being a universal nexus of causes and effects (...) . And it compelled him to believe that nature could not be orderly unless guided by a purposive force. Therefore he attacked those scientists who had thought that the world could be explained in terms of the compulsions and interactions of natural stuffs—a principle which they vaguely called Necessity, Ananke. In attacking their doctrine A. cannot have thought he was attacking the mechanistic determinism which modern critics have detected in their words: for he could not even conceive of such an idea. There is an a fortiori case for arguing that his predecessors cannot have conceived of it either. But it is always possible that A. misunderstood them. And there is still Epicurus to consider. (shrink)

Book Information Resemblance Nominalism: A Solution to the Problem of Universals. By Gonzalo Rodriguez-Pereyra. Clarendon Press. Oxford. 2002. Pp. xii + 238. £35.